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Cryogels: Recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

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posted on 2023-01-26, 10:11 authored by Luke JonesLuke Jones, Leah WilliamsLeah Williams, Tasmin Boam, Martin Kalmet, Chidubem Oguike, Fiona HattonFiona Hatton
Cryogels are macroporous polymeric structures formed from the cryogelation of monomers/polymers in a solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review highlights the fundamentals of macroporous cryogel preparation, cryogel properties that can be useful in the highlighted biomedical applications, followed by a comprehensive review of recent studies in these areas. Research evaluated includes the use of cryogels to combat various types of cancer, for implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels.

History

School

  • Mechanical, Electrical and Manufacturing Engineering
  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Beilstein Journal of Organic Chemistry

Volume

17

Pages

2553 - 2569

Publisher

Beilstein-Institut

Version

  • VoR (Version of Record)

Rights holder

© Jones et al.; licensee Beilstein-Institut

Publisher statement

This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)

Acceptance date

2021-09-21

Publication date

2021-10-14

Copyright date

2021

eISSN

1860-5397

Language

  • en

Depositor

Dr. Fiona Hatton. Deposit date: 25 January 2023

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