christie_LOC accepted Manuscript.pdf (690.46 kB)
Customisable 3D printed microfluidics for integrated analysis and optimisation
journal contributionposted on 2016-08-05, 13:29 authored by Tom Monaghan, Matthew Harding, Russell A. Harris, Ross J. Friel, Steven ChristieSteven Christie
The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.
This work was supported by the Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing.
- Mechanical, Electrical and Manufacturing Engineering
Published inLab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering
CitationMONAGHAN, T. ...et al., 2016. Customisable 3D printed microfluidics for integrated analysis and optimisation. Lab On a Chip, 16 (17), pp. 3362-3373.
Publisher© Royal Society of Chemistry
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis paper was accepted for publication in the journal Lab On a Chip and the definitive published version is available at http://dx.doi.org/10.1039/C6LC00562D.