Design criteria and applications of multi-channel parallel microfluidic module
journal contributionposted on 24.09.2018, 15:04 by Yichao Huang, Tengteng Han, Jin XuanJin Xuan, Hong Xu, Yongle Wang, Li Zhang
The microfluidic technology for function microsphere synthesis has high control precision. However, the throughput is too low for industrial scale-up applications. Current scale-up design focuses on a multi-channel in 2D, in which the distribution uniformity parameter δ increases linearly, resulting in the deterioration of the flow distribution performance. The 3D modular scale-up strategy could greatly alleviate this problem, but no design principles have been developed yet. For the first time, this paper establishes the microfluidic 3D scale-up design criteria. Based on the modular design concept, the design method of 2D and 3D throughput scale-up parameters N and M, distribution uniformity parameters δ and β, and microchannel design parameter KRwere proposed. The equivalent resistance coefficient was defined, and the influence of different parameters on a 2D array and 3D stack was analyzed. Furthermore, the error correction method was studied. It was found that the two-stage scale-up process contradicted each other. A good scale-up performance of one stage led to the limitation of another stage. Increasing the resistance of each channel Rucould both increase the two-stage scale-up performance, which was an important factor. A single-module scale-up system with 8 channels in a single array and 10 arrays in a vertical stack, which had 80 channels in total, was designed and fabricated based on the proposed design criteria for generating Chitosan/TiO2composite microspheres. The average particle size was 539.65 μm and CV value was about 3.59%. The throughput was 480 ml h-1, which effectively increased the throughput scale and the product quality.
The research was supported by the research grant (No. 16DZ2260600) from Science and Technology Commission of Shanghai Municipality, and the Fundamental Research Funds for the Central Universities (222201717012, 222201718005).
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering