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Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry
journal contributionposted on 2013-12-17, 11:46 authored by Robert W. Smith, Jim ReynoldsJim Reynolds, Sze-Ling Lee, Colin Creaser
Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.
CitationSMITH, R.W. ... et al, 2013. Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Analytical Methods, 5 (16), pp.3799-3802.
Publisher© Royal Society of Chemistry
- VoR (Version of Record)
NotesThis article is closed access.