ATVBAHA.120.315782.pdf (952.92 kB)

Distinct body mass index trajectories to young-adulthood obesity and their different cardiometabolic consequences

Download (952.92 kB)
journal contribution
posted on 16.04.2021, 15:09 by Tom Norris, Liina Mansukoski, Mark Gilthorpe, Mark Hamer, Rebecca Hardy, Laura Howe, Alun Hughes, Leah Li, Emma ODonnell, Ken Ong, George Ploubidis, Richard Silverwood, Russell Viner, Will Johnson
Objective:
Different body mass index (BMI) trajectories that result in obesity may have diverse health consequences, yet this heterogeneity is poorly understood. We aimed to identify distinct classes of individuals who share similar BMI trajectories and examine associations with cardiometabolic health.

Approach and Results:
Using data on 3549 participants in ALSPAC (Avon Longitudinal Study of Parents and Children), a growth mixture model was developed to capture heterogeneity in BMI trajectories between 7.5 and 24.5 years. Differences between identified classes in height growth curves, body composition trajectories, early-life characteristics, and a panel of cardiometabolic health measures at 24.5 years were investigated. The best mixture model had 6 classes. There were 2 normal-weight classes: normal weight (nonlinear; 35% of sample) and normal weight (linear; 21%). Two classes resulted in young-adulthood overweight: normal weight increasing to overweight (18%) and normal weight or overweight (16%). Two classes resulted in young-adulthood obesity: normal weight increasing to obesity (6%) and overweight or obesity (4%). The normal-weight-increasing-to-overweight class had more unfavorable levels of trunk fat, blood pressure, insulin, HDL (high-density lipoprotein) cholesterol, left ventricular mass, and E/e′ ratio compared with the always-normal-weight-or-overweight class, despite the average BMI trajectories for both classes converging at ≈26 kg/m2 at 24.5 years. Similarly, the normal-weight-increasing-to-obesity class had a worse cardiometabolic profile than the always-overweight-or-obese class.

Conclusions:
Individuals with high and stable BMI across childhood may have lower cardiometabolic disease risk than individuals who do not become overweight or obese until late adolescence.

Funding

Body size trajectories and cardio-metabolic resilience to obesity in three United Kingdom birth cohorts

Medical Research Council

Find out more...

British Heart Foundation (CS/15/6/31468)

History

School

  • Sport, Exercise and Health Sciences

Published in

Arteriosclerosis, Thrombosis, and Vascular Biology

Volume

41

Issue

4

Pages

1580 - 1593

Publisher

Wolters Kluwer Health, Inc.

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Wolters Kluwer Health, Inc. under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

12/02/2021

Publication date

2021-03-04

Copyright date

2021

ISSN

1079-5642

eISSN

1524-4636

Language

en

Depositor

Dr Will Johnson. Deposit date: 12 February 2021

Usage metrics

Loughborough Publications

Categories

Licence

Exports