Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation

Dulson, Deborah K.; Bishop, Nicolette

Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation

journal contribution

posted on 2016-03-08, 15:04 authored by Deborah K. Dulson, Nicolette BishopNicolette Bishop

This study investigated the effect of caffeine on antigen-stimulated lymphocyte activation. Six males rested for 3.5 h after ingesting 0 (PLA), 2, or 6 (6CAF) mg·kg−1 body mass of caffeine. The number of antigen-stimulated NK CD69+ cells increased in 6CAF at 1 h compared with PLA (P = 0.021). Caffeine did not influence the number of antigen-stimulated CD69+ T cells or the geometric mean fluorescence intensity expression of CD69 on antigen-stimulated lymphocytes, suggesting caffeine has little effect on antigen-stimulated lymphocyte activation.

History

School

Sport, Exercise and Health Sciences

Published in

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM

Volume

41

Issue

2

Pages

224 - 227

Citation

DULSON, D.K. and BISHOP, N., 2016. Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation. Applied Physiology Nutrition and Metabolism, 41 (2), pp. 224 - 227.

Publisher

NRC Research Press

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015-10-29

Notes

This is the accepted version of an article subsequently published in the journal, Applied Physiology, Nutrition, and Metabolism. The definitive version is available at: http://dx.doi.org/10.1139/apnm-2015-0456.