Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion
Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.
Objectives/Methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
History
School
- Sport, Exercise and Health Sciences
Published in
MetabolomicsVolume
20Issue
5Publisher
SpringerVersion
- VoR (Version of Record)
Rights holder
© The Author(s)Publisher statement
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Acceptance date
2024-09-19Publication date
2024-10-05Copyright date
2024ISSN
1573-3882eISSN
1573-3890Publisher version
Language
- en
