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Effect of exercise intensity on circulating hepatokine concentrations in healthy men

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journal contribution
posted on 11.02.2019, 17:12 by Scott Willis, Jack A. Sargeant, Alice ThackrayAlice Thackray, Thomas E. Yates, David StenselDavid Stensel, Guruprasad P. Aithal, James KingJames King
Fibroblast growth factor 21 (FGF21), follistatin and leukocyte cell-derived chemotaxin 2 (LECT2) are novel hepatokines which are modulated by metabolic stresses. This study investigated whether exercise intensity modulates the hepatokine response to acute exercise. Ten young, healthy men undertook three 8-h experimental trials: moderate-intensity exercise (MOD; 55% V̇O2 peak), high-intensity exercise (HIGH; 75% V̇O2 peak) and control (CON; rest), in a randomised, counterbalanced order. Exercise trials commenced with a treadmill run of varied duration to match gross exercise energy expenditure between trials (MOD vs HIGH; 2475 ± 70 vs 2488 ± 58 kJ). Circulating FGF21, follistatin, LECT2, glucagon, insulin, glucose and non-esterified fatty acids (NEFA) were measured before exercise and at 0, 1, 2, 4 and 7 h post-exercise. Plasma FGF21 concentrations were increased up to 4 h post-exercise compared to CON (P ≤ 0.022) with greater increases observed at 1, 2 and 4 h post-exercise during HIGH vs MOD (P ≤ 0.025). Irrespective of intensity (P ≥ 0.606), plasma follistatin concentrations were elevated at 4 and 7 h post-exercise (P ≤ 0.053). Plasma LECT2 concentrations were increased immediately post-exercise (P ≤ 0.046) but were not significant after correcting for plasma volume shifts. Plasma glucagon (1 h; P = 0.032) and NEFA (4 and 7 h; P ≤ 0.029) responses to exercise were accentuated in HIGH vs MOD. These findings demonstrate that acute exercise augments circulating FGF21 and follistatin. Exercise-induced changes in FGF21 are intensity-dependent and may support the greater metabolic benefit of high-intensity exercise.

Funding

National Institute for Health Research (NIHR) Leicester and Nottingham Biomedical Research Centres.

History

School

  • Sport, Exercise and Health Sciences

Published in

Applied Physiology, Nutrition, and Metabolism

Volume

44

Issue

10

Pages

1065 - 1072

Citation

WILLIS, S.A. ... et al, 2019. Effect of exercise intensity on circulating hepatokine concentrations in healthy men. Applied Physiology, Nutrition, and Metabolism, 44 (10), pp.1065-1072.

Publisher

NRC Research Press © The authors

Version

AM (Accepted Manuscript)

Publisher statement

This paper was accepted for publication in the journal Applied Physiology, Nutrition, and Metabolism and the definitive published version is available at https://doi.org/10.1139/apnm-2018-0818.

Acceptance date

04/02/2019

Publication date

2019-08-27

ISSN

1715-5312

eISSN

1715-5320

Language

en