Effect of microneedle type.pdf (838.43 kB)
Download file

Effect of microneedle type on transdermal permeation of rizatriptan

Download (838.43 kB)
journal contribution
posted on 07.04.2017, 12:37 by Chandrateja Uppuluri, Ashraf Sultana Shaik, Tao Han, Atul Nayak, Karthik J. Nair, Benjamin R. Whiteside, Buchi N. Nalluri, Diganta DasDiganta Das
The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation of rizatriptan (RIZ). Studies were carried out using two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 0.9, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PMs) of 0.6 mm length. In the case of the PMs, arrays were applied three times at different places within a 1.77-cm2 skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Histological studies revealed that PM, owing to their geometry/design, formed wider and deeper microconduits when compared to ADM of similar length. Approximately 4.9- and 4.2-fold increases in the RIZ steady-state flux values were observed with 1.5 mm ADM and PM-3 applications when compared to the passive studies. A good correlation between different dimensionless parameters like the amount of RIZ permeated (Ct/Cs), thickness (h/L) and surface area (Sa/L2) of the skin was observed with scaling analyses. Numerical simulations provided further information regarding the distribution of RIZ in MN-treated skin after application of different MNs. Overall, the study suggests that MN application enhances the RIZ transdermal permeation and the geometrical parameters of MNs play an important role in the degree enhancement.

Funding

The authors are thankful to Mylan Pharmaceuticals India Ltd, Hyderabad, for providing a gift sample of RIZ; to Dr. Naveen, Department of Pathology, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Vijayawada, for providing the required facilities for taking histological sections of skin samples; and also to the Siddhartha Academy of General and Technical Education, Vijayawada, for providing the necessary facilities to carry out the research work. The authors also extend their sincere thanks to DST, Ministry of Science and Technology, Govt. of India, and the British Council, London, UK, for funding this research work under the DST-UKIERI scheme (DST/INT/UK/P-60/2014).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

AAPS PharmSciTech

Pages

1 - 12

Citation

UPPULURI, C. ... et al, 2017. Effect of microneedle type on transdermal permeation of rizatriptan. AAPS PharmSciTech, 18(5), pp. 1495-1506.

Publisher

Springer © American Association of Pharmaceutical Scientists

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

28/12/2016

Publication date

2017

Notes

This is a post-peer-review, pre-copyedit version of an article published in AAPS PharmSciTech. The final authenticated version is available online at: http://dx.doi.org/10.1208/s12249-016-0702-0.

eISSN

1530-9932

Language

en