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Effect of microneedles on transdermal permeation enhancement of amlodipine

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journal contribution
posted on 07.04.2017, 11:09 authored by Buchi N. Nalluri, Chandrateja Uppuluri, Jyothirmayee Devineni, Atul Nayak, Karthik J. Nair, Benjamin R. Whiteside, Diganta DasDiganta Das
The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the case of PMs, arrays were applied thrice at different places within a 1.77-cm2 skin area (PM-3) to maintain the MN density closer to 0.6 mm ADM. Scaling analyses were done using dimensionless parameters like concentration of AMLO (Ct/Cs), thickness (h/L) and surface area of the skin (Sa/L2). Microinjection moulding technique was employed to fabricate PM. Histological studies revealed that the PM, owing to their geometry/design, formed wider and deeper microconduits when compared to ADM of similar length. Approximately 6.84- and 6.11-fold increase in the cumulative amount (48 h) of AMLO permeated was observed with 1.5 mm ADM and PM-3 treatments respectively, when compared to passive permeation amounts. Good correlations (R2 > 0.89) were observed between different dimensionless parameters with scaling analyses. The enhancement in AMLO permeation was found to be in the order of 1.5 mm ADM ≥ PM-3 > 1.2 mm ADM > 0.6 mm ADM ≥PM-1 > passive. The study suggests that MN application enhances the AMLO transdermal permeation and the geometrical parameters of MNs play an important role in the degree of such enhancement.

Funding

This study was funded jointly by the Department of Science and Technology (DST), Ministry of Science and Technology, Govt. of India, and the British Council, London, UK, under DST-UKIERI scheme (DST/INT/UK/P-60/2014) to Buchi N. Nalluri and Diganta B. Das.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Drug Delivery and Translational Research

Citation

NALLURI, B.N. ... et al, 2017. Effect of microneedles on transdermal permeation enhancement of amlodipine. Drug Delivery and Translational Research, 7 (3), pp. 383–394.

Publisher

Springer © Controlled Release Society

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

01/02/2017

Publication date

2017

Notes

This is a post-peer-review, pre-copyedit version of an article published in Drug Delivery and Translational Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13346-017-0361-z

ISSN

2190-393X

eISSN

2190-3948

Language

en