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Effects of a single bout of walking on postprandial triglycerides in men of Chinese, European and Japanese descent: a multisite randomised crossover trial

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journal contribution
posted on 26.11.2020, 14:06 by Chihiro Nagayama, Stephen Burns, David StenselDavid Stensel, Alice ThackrayAlice Thackray, Masaki Takahashi, Masashi Miyashita
Introduction: Elevated non-fasting triglyceride (TG) concentrations are a risk factor for cardiovascular diseases but can be reduced after acute exercise. Ethnic-based differences in the magnitude of postprandial lipaemia and the extent that acute exercise reduces postprandial TG are poorly characterised across some ethnicities including those of East Asian origin. This paper describes the protocol of a multisite randomised crossover study comparing the effect of acute walking on postprandial TG in two groups of East Asian men with European men.
Methods and analysis: Twenty Japanese, 20 Singaporean Chinese and 20 white British healthy men (21-39 years) recruited from Japan, Singapore and the UK, respectively, will complete two, 2-day trials. Fasted and postprandial venous blood samples and arterial blood pressure measurements will be taken over 6-h the day after either: (1) 60-min treadmill walking; or (2) a rest day of normal living. The primary outcome is the difference in postprandial TG among ethnic groups after rest and walking. Secondary outcomes include: cholesterol, glucose, insulin, ketone bodies, pre-heparin lipoprotein lipase, C-reactive protein and systolic/diastolic blood pressure.
Ethics and dissemination: The study was approved by the Ethics Review Committee on Research with Human Subjects of Waseda University and the Nanyang Technological University Institutional Review Board. Relevant approval will be obtained from the UK site. Research findings will be disseminated through peer-reviewed journal publication and health conferences.
Registration: This study was registered in advance with the University Hospital Medical Information Network Center, a system for registering clinical trials (ID: UMIN000038625)

Funding

Waseda University Grant for Special Research Project grant number [2019-09]

History

School

  • Sport, Exercise and Health Sciences

Published in

BMJ Open Sport and Exercise Medicine

Volume

6

Publisher

BMJ Publishing Group

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by BMJ under the Creative Commons Attribution-NonCommercial 4.0 International Licence (CC BY-NC). Full details of this licence are available at: https://creativecommons.org/licenses/by-nc/4.0/

Acceptance date

23/11/2020

Publication date

2020-12-16

Copyright date

2020

ISSN

2055-7647

Language

en

Depositor

Dr Alice Thackray Deposit date: 23 November 2020

Article number

e000928