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Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing

journal contribution
posted on 11.05.2021, 13:09 by Bin Zhang, Jehad Nasereddin, Thomas McDonagh, Didier von Zeppelin, Andy GleadallAndy Gleadall, Fahad Alqahtani, Richard BibbRichard Bibb, Peter Belton, Sheng Qi
3D printing has the unique ability to produce porous pharmaceutical solid dosage forms on-demand. Although using porosity to alter drug release kinetics has been proposed in the literature, the effects of porosity on the swellable and erodible porous solid dosage forms have not been explored. This study used a model formulation containing hypromellose acetate succinate (HPMCAS), polyethylene oxide (PEO) and paracetamol and a newly developed hot melt droplet deposition 3D printing method, Arburg plastic free-forming (APF), to examine the porosity effects on in vitro drug release. This is the first study reporting the use of APF on 3D printing porous pharmaceutical tablets. With the unique pellet feeding mechanism of APF, it is important to explore its potential applications in pharmaceutical additive manufacturing. The pores were created by altering the infill percentages (%) of the APF printing between 20 to 100% to generate porous tablets. The printing quality of these porous tablets were examined. The APF printed formulation swelled in pH 1.2 HCl and eroded in pH 6.8 PBS. During the dissolution at pH 1.2, the swelling of the printing pathway led to the gradual decreases in the open pore area and complete closure of pores for the tablets with high infills. In pH 6.8 buffer media, the direct correlation between drug release rate and infills was observed for the tablets printed with infill at and less than 60%. The results revealed that drug release kinetics were controlled by the complex interplay of the porosity and dynamic changes of the tablets caused by swelling and erosion. It also implied the potential impact of fluid hydrodynamics on the in vitro data collection and interpretation of porous solids.

Funding

Enabling Innovation: Research to Application (EIRA), a Research England Connecting Capability Fund (CCF) projec

History

School

  • Design and Creative Arts
  • Mechanical, Electrical and Manufacturing Engineering

Department

  • Design

Published in

International Journal of Pharmaceutics

Volume

604

Publisher

Elsevier

Version

AM (Accepted Manuscript)

Rights holder

© Elsevier

Publisher statement

This paper was accepted for publication in the journal International Journal of Pharmaceutics and the definitive published version is available at https://doi.org/10.1016/j.ijpharm.2021.120626

Acceptance date

17/04/2021

Publication date

2021-05-03

Copyright date

2021

ISSN

0378-5173

Language

en

Depositor

Prof Richard Bibb. Deposit date: 19 April 2021

Article number

120626