Sargeant EJAP Sprint interval training in men with NAFLD.pdf (1023.51 kB)
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Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease

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posted on 02.02.2018, 13:55 authored by Jack Sargeant, Stephen Bawden, Guruprasad P. Aithal, Elizabeth J. Simpson, Ian MacDonald, Mark Turner, Jessica Cegielski, Kenneth Smith, James L. Dorling, Penny Gowland, Myra A. Nimmo, James KingJames King
Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral (VAT) and subcutaneous adipose tissue (ScAT). Methods: Nine men with NAFLD (age 41±8 years; BMI 31.7±3.1 kg·m-2; IHTG 15.6±8.3%) were assessed at: 1) baseline 2) after a control phase of no intervention (pre-training) and 3) after six weeks of SIT (4-6 maximal 30 s cycling intervals, three times per week). IHTG, VAT and ScAT were measured using magnetic resonance spectroscopy or imaging and insulin sensitivity was assessed via dual-step hyperinsulinaemic-euglycaemic clamp with [6,6-D2] glucose tracer. Results: Participants adhered to SIT, completing ≥96.7% of prescribed intervals. SIT increased peak oxygen uptake (V̇O2 peak: +13.6% [95% CI: 8.8 to 18.2%]) and elicited a relative reduction in IHTG (-12.4% [-31.6 to 6.7%]) and VAT (-16.9% [-24.4 to -9.4%]; n=8), with no change in body weight or ScAT. Peripheral insulin sensitivity increased throughout the study (n=8; significant main effect of phase) but changes from pre- to post-training were highly variable (range: -18.5 to +58.7%) and not significant (P=0.09), despite a moderate effect size (g*=0.63). Hepatic insulin sensitivity was not influenced by SIT. Conclusions: SIT is feasible for men with NAFLD in a controlled laboratory setting and is able to reduce IHTG and VAT in the absence of weight loss.

History

School

  • Sport, Exercise and Health Sciences

Published in

European Journal of Applied Physiology

Citation

SARGEANT, J.A. ... et al, 2018. Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118 (4), pp.817–828.

Publisher

© Springer Verlag

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

29/01/2018

Publication date

2018-02-06

Notes

This is a post-peer-review, pre-copyedit version of an article published in European Journal of Applied Physiology. The final authenticated version is available online at: https://doi.org/10.1007/s00421-018-3818-y

ISSN

1439-6319

eISSN

1439-6327

Language

en