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Egyptian corals-based calcium silicate (CaS) nanopowders doped with zinc/copper for improved chemical stability and treatment of calvarial defects

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posted on 2023-01-03, 16:07 authored by Mostafa Mabrouk, Sahar M Mousa, Mohamed B Shalaby, Aziza B Shalby, Hanan H Beherei, Diganta DasDiganta Das

Developing low-cost nano-biomaterials using locally available raw materials is gaining significant prominence recently, e.g., to meet the UN’s sustainable development goals (Goal 3). In this work, amorphous calcium silicate (CaS) nanopowders were prepared from Egyptian corals (CaCO3) as a low-cost bone restoration material due to their excellent bonding abilities with surrounding bone tissues, which in turn accelerated the bone healing process. Some of the developed CaS nanopowders was doped with different concentrations of Cu2+ and Zn2+ at the expense of the inherent Ca2+ in the raw materials. The nanopowders were characterized using X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), scanning electron microscope with energy-dispersive X-ray spectrometry (SEM-EDX), transmission electron microscope (TEM) and Brunauer-Emmett-Teller (BET) surface area measurements. Mechanical and bactericidal properties of the nanopowders were assessed followed by well-defined examinations of their abilities to support cell viability, proliferation and differentiation against osteosarcoma cells (MG63 cell lines). The obtained nanopowders were confirmed to be amorphous in nature with particle diameters mostly in two size ranges, namely, 5–10 nm and 15–92 nm. The nanopowders were found to have a good surface area influenced by the type of dopant materials. Notable enhancement in the mechanical (up to 6.76 MPa compressive strength) and antibacterial behaviors of the CaS nanopowders were observed after Zn2+ doping. The number of the differentiated cells after 72 h of incubation was increased, especially for CaS silicate Zn2+ doped nanopowders. Following these examinations of the nanopowders, their utility for the treatment of calvarial (top part of the skull) defects in a rat model was investigated. The developed Cu2+ or Zn2+ doped nanopowders enhanced the healing rate of calvarial defects and they demonstrated impressive biosafety towards repairing vital organs (brain, liver and kidney).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volume

660

Publisher

Elsevier

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

2022-12-24

Publication date

2022-12-24

Copyright date

2022

ISSN

0927-7757

Language

  • en

Depositor

Dr Diganta Das. Deposit date: 29 December 2022

Article number

130875

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