Skarabot et al 2018 EJN accepted.pdf (858.19 kB)
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Electrical stimulation of human corticospinal axons at the level of the lumbar spinal segments

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posted on 10.03.2021, 10:00 authored by Jakob SkarabotJakob Skarabot, Paul Ansdell, Callum G Brownstein, Kevin Thomas, Glyn Howatson, Stuart Goodall, Rade Durbaba
Electrical stimulation over the mastoids or thoracic spinous processes has been used to assess subcortical contribution to corticospinal excitability, but responses are difficult to evoke in the resting lower limbs or are limited to only a few muscle groups. This might be mitigated by delivering the stimuli lower on the spinal column, where the descending tracts contain a greater relative density of motoneurons projecting to lower limb muscles. We investigated activation of the corticospinal axons innervating tibialis anterior (TA) and rectus femoris (RF) by applying a single electrical stimulus over the first lumbar spinous process (LS). LS was paired with transcranial magnetic stimulation (TMS) at interstimulus intervals (ISIs) of −16 (TMS before LS) to 14 ms (LS before TMS). The relationship between muscle contraction strength (10%–100% maximal) and the amplitude of single‐pulse TMS and LS responses was also investigated. Compared to the responses to TMS alone, responses to paired stimulation were significantly occluded in both muscles for ISIs ≥−8 ms (p ≤ 0.035), consistent with collision of descending volleys from TMS with antidromic volleys originating from LS. This suggests that TMS and LS activate some of the same corticospinal axons. Additionally, the amplitude of TMS and LS responses increased with increasing contraction strengths with no change in onset latency, suggesting responses to LS are evoked transsynaptically and have a monosynaptic component. Taken together, these experiments provide evidence that LS is an alternative method that could be used to discern segmental changes in the corticospinal tract when targeting lower limb muscles.

History

School

  • Sport, Exercise and Health Sciences

Published in

European Journal of Neuroscience

Volume

49

Issue

10

Pages

1254 - 1267

Publisher

Wiley

Version

AM (Accepted Manuscript)

Rights holder

© Federation of European Neuroscience Societies and John Wiley & Sons Ltd

Publisher statement

This is the peer reviewed version of the following article: ŠKARABOT, J. ... et al, 2019. Electrical stimulation of human corticospinal axons at the level of the lumbar spinal segments. European Journal of Neuroscience, 49 (10), pp.1254-1267, which has been published in final form at https://doi.org/10.1111/ejn.14321. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Acceptance date

18/12/2018

Publication date

2019-01-16

Copyright date

2018

ISSN

0953-816X

eISSN

1460-9568

Language

en

Depositor

Dr Jakob Skarabot. Deposit date: 9 March 2021