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Electrospinning of stimuli-responsive polymers for controlled drug delivery: pH- and temperature-driven release

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posted on 2022-06-28, 09:48 authored by Leah Williams, Fiona HattonFiona Hatton, Helen WillcockHelen Willcock, Elisa MeleElisa Mele
Stimuli-responsive polymers have attracted academic interest over the last 60 years due to their potential use in developing systems with a range of functionalities that can be activated by external artificial triggers. The diversity of responses and stimuli, which can be achieved through careful polymer selection and processing, opens up applications in nearly every sector. In particular, the use of responsive polymers for the controlled delivery of drugs and bioactive compounds has been heavily researched. This review provides an overview of the recent advancements in electrospinning of temperature- and pH-responsive polymers to create networks of nanofibres with controlled drug delivery profiles for biomedical applications.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Biotechnology and Bioengineering

Volume

119

Issue

5

Pages

1177 - 1188

Publisher

Wiley

Version

  • AM (Accepted Manuscript)

Rights holder

© Wiley

Publisher statement

This is the peer reviewed version of the following article: Williams, L., Hatton, F. L., Willcock, H., & Mele, E. (2022). Electrospinning of stimuli-responsive polymers for controlled drug delivery: pH- and temperature-driven release. Biotechnology and Bioengineering, 119, 1177– 1188, which has been published in final form at https://doi.org/10.1002/bit.28043. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Acceptance date

2022-01-17

Publication date

2022-02-04

Copyright date

2022

DOI

ISSN

0006-3592

eISSN

1097-0290

Publisher version

Language

  • en

Depositor

Dr Elisa Mele. Deposit date: 23 June 2022

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    Loughborough Publications

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    Keywords

    drug deliveryelectrospinningresponsive polymers

    Licence

    CC BY-NC-ND 4.0

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