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Electrostatics of polymer translocation events in electrolyte solutions

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posted on 19.01.2018, 14:10 by Sahin Buyukdagli, Tapio Ala-NissilaTapio Ala-Nissila
© 2016 Author(s).We develop an analytical theory that accounts for the image and surface charge interactions between a charged dielectric membrane and a DNA molecule translocating through the membrane. Translocation events through neutral carbon-based membranes are driven by a competition between the repulsive DNA-image-charge interactions and the attractive coupling between the DNA segments on the trans and the cis sides of the membrane. The latter effect is induced by the reduction of the coupling by the dielectric membrane. In strong salt solutions where the repulsive image-charge effects dominate the attractive trans-cis coupling, the DNA molecule encounters a translocation barrier of ∼10 kBT. In dilute electrolytes, the trans-cis coupling takes over image-charge forces and the membrane becomes a metastable attraction point that can trap translocating polymers over long time intervals. This mechanism can be used in translocation experiments in order to control DNA motion by tuning the salt concentration of the solution.

History

School

  • Science

Department

  • Mathematical Sciences

Published in

Journal of Chemical Physics

Volume

145

Issue

1

Citation

BUYUKDAGLI, S. and ALA-NISSILA, T., 2016. Electrostatics of polymer translocation events in electrolyte solutions. Journal of Chemical Physics, 145: 014902.

Publisher

© the Authors. Published by AIP Publishing

Version

VoR (Version of Record)

Acceptance date

15/06/2016

Publication date

2016

Notes

This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in BUYUKDAGLI, S. and ALA-NISSILA, T., 2016. Electrostatics of polymer translocation events in electrolyte solutions. Journal of Chemical Physics, 145: 014902 and may be found at https://doi.org/10.1063/1.4954919

ISSN

0021-9606

Language

en

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