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Emulsion templating of poly(lactic acid) particles: droplet formation behavior

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posted on 03.10.2012, 11:58 authored by Goran VladisavljevicGoran Vladisavljevic, Wynter J. Duncanson, Ho Cheung Shum, David A. Weitz
Monodisperse poly(dl-lactic acid) (PLA) particles of diameters between 11 and 121 ?m were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1−2 mM Nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002−7.2 cm3h-1), continuous phase flow rates (0.3−30 cm3h-1) and orifice diameters (50−237 ?m). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2 % and a ratio of the droplet diameter to orifice diameter of 0.5−1 were obtained at flow rate ratios of 4−25. Under jetting regime, polydisperse droplets (CV > 6 %) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size was 2−5.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

VLADISAVLJEVIC, G.T. ... et al, 2012. Emulsion templating of poly(lactic acid) particles: droplet formation behavior. Langmuir, 28 (36), pp.12948-12954.

Publisher

© American Chemical Society

Version

AM (Accepted Manuscript)

Publication date

2012

Notes

This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Langmuir, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/doi/abs/10.1021/la302092f

ISSN

0743-7463

eISSN

1520-5827

Language

en