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End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation

journal contribution
posted on 22.07.2014, 11:38 authored by Salvatore Mascia, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim BenyahiaBrahim Benyahia, Paul I. Barton, Richard D. Braatz, Charles L. Cooney, James M.B. Evans, Timothy F. Jamison, Klavs F. Jensen, Allan S. Myerson, Bernhardt L. Trout
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Angewandte Chemie - International Edition

Volume

52

Issue

47

Pages

12359 - 12363

Citation

MASCIA, S. ... et al, 2013. End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation. Angewandte Chemie - International Edition, 52 (47), pp.12359-12363.

Publisher

© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Version

VoR (Version of Record)

Publication date

2013

Notes

This paper is closed access.

ISSN

1433-7851

eISSN

1521-3773

Language

en