<p dir="ltr">Additive manufacturing (AM) is increasingly employed in the development of 3D-printed wearables, including medical wrist supports, textiles, and protective garments. While the general tribological behavior of 3D-printed components has been widely studied, limited research has focused on the friction behavior of 3D-printed wearables when in contact with human skin, which is a crucial factor for improving wearer comfort by minimizing local skin friction. This study, therefore, investigates the influence of material type, manufacturing technology, and print parameters on frictional behavior against skin. Specimens were fabricated using three AM technologies: material extrusion (MEX), vat photopolymerization (VATP), and powder bed fusion (PBF). Each technology employed various materials and print parameters, specifically layer thickness (ranging from 0.05 to 0.3 mm) and print orientations (horizontal and vertical). Friction was measured using a custom-built handheld device at the interface between 3D-printed specimens and two surrogate skin models: lorica (representing the dorsal forearm) and silicone (representing the chest). Results revealed that friction is significantly influenced by both layer thickness and print orientation. For MEX specimens, ABS, ASA, and PC showed the highest friction, while for VATP, Durable resin resulted in the highest friction coefficient. In contrast, PBF specimens exhibited very similar frictional behavior. Regarding layer thickness, higher values consistently resulted in the highest friction coefficients, regardless of manufacturing method or material type. These findings provide valuable insights for designers and engineers seeking to optimize the comfort of 3D-printed wearables, guiding the selection of suitable AM processes and parameters for products intended for direct skin contact.</p>