Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women
journal contributionposted on 2018-05-29, 11:02 authored by Matheus Uba Chupel, Luciele G. Minuzzi, Guilherme Eustaquio Furtado, Mario L. Santos, Eef HogervorstEef Hogervorst, Edith Filaire, Ana Maria Teixeira
Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of blood-brain barrier, inflammation, and cognition of elderly women. Forty-eight elderly women (83.58±6.9 years) participated in the study, and were allocated into combined exercise training (CET: n=13), taurine supplementation (TAU: n=12), exercise training associated with taurine (CET+TAU: n=11), or control group (CG: n=12). Exercise was applied twice a week (multi-modal exercise). Taurine ingestion was 1.5g., once a day. Participants were evaluated before and after 14-weeks of intervention. Plasma levels of IL-1β, IL-1ra, IL-6, IL-10, IL-17, TNF-α, and serum concentration of S100β and neuron specific enolase (NSE) were determined. The mini mental state examination (MMSE) was also applied. Concentrations of S100β were maintained in all intervention groups, while a subtle increase in the CG was found. NSE levels increased only in TAU group (p<0.05). CET reduced TNF-α, IL-6, and IL-1β/IL-1ra, IL-6/IL10, TNF-α/IL-10 ratios (p<0.05). TAU decreased the IL-1β/IL-1ra ratio (p<0.05). MMSE score increased only in CET+TAU group (p<0.05). Multiple regression analysis showed that there was a trend for changes in IL-1β and CCI to be independently associated with changes in S100β. Exercise and taurine decreased inflammation, and maintained the BBB integrity in elderly women. Exercise emerged as an important tool to improve brain health even when started at advanced ages.
This work was partly supported by FEDER funding through COMPETE and the National funding through FCT – Portuguese Foundation for Science and Technology by grant [PTDC/DTPDES/0154/2012](UID/PTD/04213/2016); Chupel, Minuzzi and Furtado were financed by grant from CAPES/CNPQ (BEX: 13642-13/8, 1417/3-4 and 11929-13/8, respectively), Ministry of Education, Brazil.
- Sport, Exercise and Health Sciences