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Exercise for premenstrual syndrome: A systematic review and meta-analysis of randomised controlled trials

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journal contribution
posted on 22.03.2021, 14:18 by E Pearce, K Jolly, LL Jones, G Matthewman, M Zanganeh, Amanda Daley
© 2020, The Authors. Background: Exercise is recommended as a treatment for premenstrual syndrome (PMS) in clinical guidelines, but this is currently based on poor-quality trial evidence. Aim: To systematically review the evidence for the effectiveness of exercise as a treatment for PMS. Design & setting: This systematic review searched eight major databases, including MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL), and two trial registries from inception until April 2019. Method: Randomised controlled trials (RCTs) comparing exercise interventions of a minimum of 8-weeks duration with non-exercise comparator groups in women with PMS were included. Mean change scores for any continuous PMS outcome measure were extracted from eligible trials and standardised mean differences (SMDs) were calculated where possible. Random-effects meta-analysis of the effect of exercise on global PMS symptoms was the primary outcome. Secondary analyses examined the effects of exercise on predetermined clusters of psychological, physical, and behavioural symptoms. Results: A total of 436 non-duplicate returns were screened, with 15 RCTs eligible for inclusion (n = 717). Seven trials contributed data to the primary outcome meta-analysis (n = 265); participants randomised to an exercise intervention reported reduced global PMS symptom scores (SMD = -1.08; 95% confidence interval [CI] = -1.88 to -0.29) versus comparator, but with substantial heterogeneity (I2 = 87%). Secondary results for psychological (SMD = -1.67; 95% CI = -2.38 to -0.96), physical (SMD = -1.62; 95% CI = -2.41 to -0.83) and behavioural (SMD = -1.94; 95% CI = -2.45 to -1.44) symptom groupings displayed similar findings. Most trials (87%) were considered at high risk of bias. Conclusion: Based on current evidence, exercise may be an effective treatment for PMS, but some uncertainty remains.

History

School

  • Sport, Exercise and Health Sciences

Published in

BJGP Open

Volume

4

Issue

3

Publisher

BMJ

Version

VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by BMJ under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

29/11/2019

Publication date

2020-06-10

Copyright date

2020

ISSN

1849-5435

eISSN

2398-3795

Language

en

Depositor

Prof Amanda Daley. Deposit date: 17 March 2021

Article number

bjgppen20X101032

Licence

Exports

Loughborough Publications

Categories

Licence

Exports