M 2022 Exploring the Mechanical Properties and Performance of Type-I Collagen at Various Length Scales - A Progress Report.pdf (600.12 kB)
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Exploring the mechanical properties and performance of type-I collagen at various length scales: a progress report

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journal contribution
posted on 09.05.2022, 08:15 by Shirsha Bose, Simin LiSimin Li, Elisa MeleElisa Mele, Vadim SilberschmidtVadim Silberschmidt
Collagen is the basic protein of animal tissues and has a complex hierarchical structure. It plays a crucial role in maintaining the mechanical and structural stability of biological tissues. Over the years, it has become a material of interest in the biomedical industries thanks to its excellent biocompatibility and biodegradability and low antigenicity. Despite its significance, the mechanical properties and performance of pure collagen have been never reviewed. In this work, the emphasis is on the mechanics of collagen at different hierarchical levels and its long-term mechanical performance. In addition, the effect of hydration, important for various applications, was considered throughout the study because of its dramatic influence on the mechanics of collagen. Furthermore, the discrepancies in reports of the mechanical properties of collagenous tissues (basically composed of 20–30% collagen fibres) and those of pure collagen are discussed.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering
  • Mechanical, Electrical and Manufacturing Engineering

Department

  • Materials

Published in

Materials

Volume

15

Issue

8

Publisher

MDPI AG

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

06/04/2022

Publication date

2022-04-08

Copyright date

2022

eISSN

1996-1944

Language

en

Depositor

Prof Vadim Silberschmidt. Deposit date: 5 May 2022

Article number

2753