M 2022 Exploring the Mechanical Properties and Performance of Type-I Collagen at Various Length Scales - A Progress Report.pdf (600.12 kB)
Download fileExploring the mechanical properties and performance of type-I collagen at various length scales: a progress report
journal contribution
posted on 2022-05-09, 08:15 authored by Shirsha Bose, Simin LiSimin Li, Elisa MeleElisa Mele, Vadim SilberschmidtVadim SilberschmidtCollagen is the basic protein of animal tissues and has a complex hierarchical structure. It plays a crucial role in maintaining the mechanical and structural stability of biological tissues. Over the years, it has become a material of interest in the biomedical industries thanks to its excellent biocompatibility and biodegradability and low antigenicity. Despite its significance, the mechanical properties and performance of pure collagen have been never reviewed. In this work, the emphasis is on the mechanics of collagen at different hierarchical levels and its long-term mechanical performance. In addition, the effect of hydration, important for various applications, was considered throughout the study because of its dramatic influence on the mechanics of collagen. Furthermore, the discrepancies in reports of the mechanical properties of collagenous tissues (basically composed of 20–30% collagen fibres) and those of pure collagen are discussed.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
- Mechanical, Electrical and Manufacturing Engineering
Department
- Materials
Published in
MaterialsVolume
15Issue
8Publisher
MDPI AGVersion
- VoR (Version of Record)
Rights holder
© The AuthorsPublisher statement
This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/Acceptance date
2022-04-06Publication date
2022-04-08Copyright date
2022eISSN
1996-1944Publisher version
Language
- en