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Exploring the potential of salivary and blood immune biomarkers to elucidate physical frailty in institutionalized older women

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journal contribution
posted on 16.07.2020, 09:51 by Guilherme Eustáquio Furtado, Matheus Uba Chupel, Luciele Minuzzi, Miguel Patrício, Marisa Loureiro, Stephan Bandelow, Eef HogervorstEef Hogervorst, José Pedro Ferreira, Ana Maria Teixeira
Identification of older populations at increased risk of physical frailty using biochemical approaches could improve screening accuracy. The aim of this study was to study the relationship between immune markers and independent components of physical frailty in institutionalized older women. A sample of 358 institutionalized-dwelling women, aged 75 years and older, were assessed for biosocial factors and general health status, pro and anti-inflammatory cytokines, sex steroid hormones, salivary anti-microbial proteins, blood cells counts and the five Fried's physical frailty components that allowed for classification of the sample into frail, prefrailty and not-frail subgroups. Results showed that cytokines IL-6, IL-10, IL-1β, TNF-α, and the TNF-α/IL-10 ratio, mean corpuscular haemoglobin, salivary cortisol and α-amylase were all associated with frailty. Weakness and Exhaustion were the frailty components that were most strongly associated with these biomarkers. Salivary α-amylase was the biomarker that best explained frailty, as it was associated with all five components of physical frailty, and could be used as a potential screening tool. Future research needs to investigate the causal-effect association between salivary innate immune makers, susceptibility to infection and frailty.

Funding

Portuguese National Funding Agency for Science, Research and Technology (FCT), it was integrated as a sub-project in the “PRO-HMESCI: Hormonal mediation of exercise on cognition, stress and immunity” study protocol [FCT PTDC/DTP-DES/0154/2012].

CAPES/CNPQ – Ministry of Education – Brazil, reference BEX: 11929/13-8

CAPES/CNPQ – Ministry of Education – Brazil, reference BEX: 13642/13-8

History

School

  • Sport, Exercise and Health Sciences

Published in

Experimental Gerontology

Volume

129

Pages

110759

Publisher

Elsevier

Version

AM (Accepted Manuscript)

Rights holder

© Elsevier

Publisher statement

This paper was accepted for publication in the journal Experimental Gerontology and the definitive published version is available at https://doi.org/10.1016/j.exger.2019.110759

Acceptance date

21/10/2019

Publication date

2019-10-31

Copyright date

2019

ISSN

0531-5565

eISSN

1873-6815

Language

en

Depositor

Prof Eef Hogervorst . Deposit date: 15 July 2020

Article number

110759