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Facile asymmetric construction of a functionalized dodecahydrobenz[a]indolo[3,2-h]quinolizine template
journal contributionposted on 2011-11-08, 14:14 authored by Steven M. Allin, Liam J. Duffy, Joannah M.R. Towler, Philip C. Bulman Page, Mark ElsegoodMark Elsegood, Basu Saha
We report a highly diastereoselective approach for the synthesis of a functionalized dodecahydrobenz[a]indolo[3,2-h]quinolizine ring system that is present as the heterocyclic core of the manadomanzamine alkaloids. We have achieved complete control over the relative and absolute stereochemistries at the three contiguous stereocentres at ring positions 1, 10 and 24 in only two linear synthetic steps. The introduction of useful functionality to the heterocyclic skeleton is significant as this may allow for future derivatization, and application of this route in an asymmetric synthesis of the manadomanzamine natural products.
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
CitationALLIN, S.M. ... et al, 2009. Facile asymmetric construction of a functionalized dodecahydrobenz[a]indolo[3,2-h]quinolizine template. Tetrahedron, 65 (49), pp. 10230-10234
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NotesThis article is Closed Access, it was published in the journal, Tetrahedron [© Elsevier]. The definitive version is available from: http://www.sciencedirect.com/science/article/pii/S0040402009014689