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First asymmetric synthesis of the natural enantiomer of the indolizidino[8,7-b]indole alkaloid harmicine

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journal contribution
posted on 26.06.2007, 13:32 by Steven Allin, Sean N. Gaskell, Mark ElsegoodMark Elsegood, William P. Martin
We report a novel, facile and asymmetric approach for the synthesis of the indole alkaloid harmicine via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step, and verify the relative stereochemistry of the key synthetic intermediate in this approach through X-ray crystallography.

History

School

  • Science

Department

  • Chemistry

Citation

ALLIN, S.M ... et al, 2007. A new asymmetric synthesis of the natural enantiomer of the indolizidino[8,7-b]indole alkaloid (+)-harmicine. Tetrahedron letters, 48 (32), 6 August, pp. 5669-5671

Publisher

© Elsevier

Publication date

2007

Notes

This article was published in the journal, Tetrahedron letters [© Elsevier]. The definitive version is available at: http://www.sciencedirect.com/science/journal/00404039.

ISSN

0040-4039

Language

en

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