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Flow-mediated dilation is acutely improved after high-intensity interval exercise

journal contribution
posted on 20.11.2014, 10:16 by Katharine D. Currie, Robert S. McKelvie, Maureen Macdonald
Purpose: Cardiovascular disease is characterized by decreased endothelial function. Chronic exercise training improves endothelial function in individuals with cardiovascular diseases; however, the acute endothelial responses to a single bout of exercise are not consistent in the literature. This study investigated whether a single bout of moderate-intensity endurance exercise (END) and low-volume high-intensity interval exercise (HIT) on a cycle ergometer resulted in similar acute changes in endothelial function. Methods: Ten individuals (66 ± 11 yr) with coronary artery disease (CAD) participated in two exercise sessions (END and HIT). Endothelial-dependent function was assessed using brachial artery flow-mediated dilation (FMD) preexercise and 60 min postexercise. Brachial artery diameters and velocities were determined using Doppler ultrasound before and after a 5 min ischemic period at all time points. Endothelial-independent function was assessed using a 0.4-mg sublingual dose of nitroglycerin. Results: The total work performed was higher in END (166 ± 52 kJ) compared with HIT (93 ± 28 kJ) exercise (P < 0.001). Endothelial-dependent function improved (P = 0.01) after END (absolute FMD preexercise, 0.24 ± 0.18 mm; postexercise, 0.31 ± 0.24 mm) and HIT (absolute FMD preexercise, 0.25 ± 0.13 mm; postexercise, 0.29 ± 0.13 mm), with no differences between exercise conditions. A time effect for FMD normalized to the shear rate area under the curve was also observed (P = 0.02) after END (preexercise, 0.005 ± 0.004; postexercise, 0.010 ± 0.011) and HIT (preexercise, 0.005 ± 0.004; postexercise, 0.009 ± 0.011). Endothelial-independent function responses were unchanged after END and HIT (P > 0.05). Conclusions: HIT and END resulted in similar acute increases in brachial artery endothelial-dependent function in a population with dysfunction at rest, despite the difference in exercise intensities.

Funding

This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).

History

School

  • Sport, Exercise and Health Sciences

Published in

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Volume

44

Issue

11

Pages

2057 - 2064 (8)

Citation

CURRIE, K.D., MCKELVIE, R.S. and MACDONALD, M.J., 2012. Flow-mediated dilation is acutely improved after high-intensity interval exercise. Medicine and Science in Sports and Exercise, 44 (11), pp.2057-2064.

Publisher

Lippincott Williams & Wilkins (© American College of Sports Medicine)

Version

NA (Not Applicable or Unknown)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2012

Notes

This paper is closed access.

ISSN

0195-9131

Language

en