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GDF15 provides an endocrine signal of nutritional stress in mice and humans

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posted on 2019-02-01, 13:47 authored by Satish Patel, Anna Alvarez-Guaita, Audrey Melvin, Debra Rimmington, Alessia Dattilo, Emily L. Miedzybrodzka, Irene Cimino, Anne-Catherine Maurin, Geoffrey P. Roberts, Claire L. Meek, Samuel Virtue, Lauren M. Sparks, Stephanie A. Parsons, Leanne M. Redman, George A. Bray, Alice P. Liou, Rachel M. Woods, Sion A. Parry, Per B. Jeppesen, Anders J. Kolnes, Heather P. Harding, David Ron, Antonio Vidal-Puig, Frank Reimann, Fiona M. Gribble, Carl Hulston, I. Sadaf Farooqi, Pierre Fafournoux, Steven R. Smith, Jorgen Jensen, Danna Breen, Zhidan Wu, Bei B. Zhang, Anthony P. Coll, David B. Savage, Stephen O’Rahilly
GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological role in energy balance. We performed experiments in humans, mice, and cells to determine if and how nutritional perturbations modify GDF15 expression. Circulating GDF15 levels manifest very modest changes in response to moderate caloric surpluses or deficits in mice or humans, differentiating it from classical intestinally derived satiety hormones and leptin. However, GDF15 levels do increase following sustained high-fat feeding or dietary amino acid imbalance in mice. We demonstrate that GDF15 expression is regulated by the integrated stress response and is induced in selected tissues in mice in these settings. Finally, we show that pharmacological GDF15 administration to mice can trigger conditioned taste aversion, suggesting that GDF15 may induce an aversive response to nutritional stress.

Funding

HS6 is supported in part by a grant from the US Department of Agriculture: 2010-34323-21052. Mouse Studies 1, 2, and 3 are supported by The Disease Model Core, part of the MRC Metabolic Diseases Unit (MRC_MC_UU_12012/5), and Wellcome Trust Strategic Award (100574/Z/12/Z). D.B.S. and S.O.R. are supported by the Wellcome Trust (WT 107064 and WT 095515/Z/11/Z), the MRC Metabolic Disease Unit (MRC_MC_UU_12012.1), and The National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre and NIHR Rare Disease Translational Research Collaboration. A.P.C., D. Rimmington, and I.C. are supported by the Medical Research Council (MRC Metabolic Diseases Unit [MRC_MC_UU_12012.1]). D. Ron is supported by a Wellcome Trust Principal Research Fellowship (Wellcome 200848/Z/16/Z) and a Wellcome Trust Strategic Award to the Cambridge Institute for Medical Research (Wellcome 100140). A.V.-P. and S.V. are supported by the BHF (RG/12/13/29853) and MRC (MC_UU_12012/2). I.S.F. was supported by the Wellcome Trust (098497/Z/12/Z), European Research Council, NIHR Cambridge Biomedical Research Centre, and Bernard Wolfe Health Neuroscience Endowment. A.M. is supported by a studentship from the Experimental Medicine Training Initiative/AstraZeneca. G.P.R. was supported by an Addenbrooke’s Charitable Trust/Evelyn Trust Cambridge Clinical Research Fellowship (16-69), an EFSD project grant, and a Royal College of Surgeons Research Fellowship. C.L.M. is supported by the Diabetes UK Harry Keen intermediate clinical fellowship (17/0005712). F.M.G. and F.R. are supported by the MRC (MRC_MC_UU_12012/3), Wellcome Trust (106262/Z/14/Z and 106263/Z/14/Z), and research grants from Medimmune.

History

School

  • Sport, Exercise and Health Sciences

Published in

Cell Metabolism

Volume

29

Issue

3

Pages

707-718.e8

Citation

PATEL, S. ... et al, 2018. GDF15 provides an endocrine signal of nutritional stress in mice and humans. Cell Metabolism, 29(3), pp.707-718.e8.

Publisher

Elsevier © The authors

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

2018-12-17

Publication date

2019-01-10

Copyright date

2019

Notes

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

1550-4131

Language

  • en

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