Suhaimi&Das_BILE_Sept2015_Final copy.pdf (1.01 MB)
Download file

Glucose diffusivity in cell-seeded tissue engineering scaffolds

Download (1.01 MB)
journal contribution
posted on 16.09.2015, 15:35 by Hazwani Suhaimi, Diganta DasDiganta Das
Objective: A series of well-defined diffusion experiments was carried out to determine the effective glucose diffusion coefficient in cell-seeded porous scaffolds to understand the importance of nutrient diffusion in tissue engineering bioreactor. Results Cell growth changed the morphological structure of the scaffolds reducing the effective pore space and inevitably decreased the effective glucose diffusivity in the chosen scaffolds, namely, collagen, poly(L-lactide) and poly(caprolactone) scaffolds from 3.71 x 10-9 m2/s to 3.23 x 10-9 m2/s, 1.39 x 10-10 m2/s to 9.09 x 10-11 m2/s and 1.78 x 10-10 m2/s to 1.32 x 10-10 m2/s, respectively. Conclusions The presence of cells over time during cell culture reduces the mobility of glucose. The results of this study should be possible to use to predict the glucose concentration profiles in thick engineered tissues.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Biotechnology Letters

Citation

SUHAIMI, H. and DAS, D.B., 2016. Glucose diffusivity in cell-seeded tissue engineering scaffolds. Biotechnology Letters, 38(1), pp.183-190.

Publisher

© Springer Science+Business Media Dordrecht

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2016

Notes

The final publication is available at Springer via http://dx.doi.org/10.1007/s10529-015-1958-2

ISSN

0141-5492

eISSN

1573-6776

Language

en