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Habitual aerobic exercise in healthy postmenopausal women does not augment basal cardiac autonomic activity yet modulates autonomic-metabolic interactions

journal contribution
posted on 21.06.2022, 15:15 authored by Emma ODonnellEmma ODonnell, Jen CraigJen Craig

Objective: 

The aim of the present study was to examine the effects of habitual exercise training and metabolic health on basal cardiac autonomic function and cardiac autonomic recovery after exercise in healthy postmenopausal women (PMW).

Methods: 

Habitually aerobically trained PMW (PMW-tr; 56 ± 1y; n = 11), and untrained PMW (PMW-un; 57 ± 1y; n= 13) and premenopausal women (PreM; ages 26 ± 1y; n= 14) were studied. Cardiac autonomic function, assessed using heart rate variability (HRV), was measured before and one hour after 45-minutes of moderate-intensity exercise (60% VO2peak). Fast Fourier frequency domain measures of high (HF; 0.15 Hz-0.4 Hz), low (LF; 0.04 Hz-0.15 Hz), very low (VLF; 0.01 Hz-0.04 Hz), and Total (VLF + LF + HF) HRV were assessed. Serum estradiol, insulin, and glucose were determined, and HOMA-IR, an index of insulin resistance, was calculated.

Results: 

In PMW groups, body composition and serum markers did not differ (P > 0.05). Pre-exercise, heart rate was lower (P < 0.05) in PMW-tr than PMW-un, yet HRV did not differ (P > 0.05). In PMW-tr only, HF was inversely associated (P < 0.05) with insulin (r = -0.738) and HOMA-IR (r = -0.758). In PreM, HRV was higher than PMW (P< 0.05) and was positively correlated with estradiol (P< 0.05). Postexercise, HRV was decreased within all groups (P< 0.05) yet remained higher in PreM (P< 0.05), and similar (P> 0.05) between PMW.

Conclusions: 

Basal and postexercise HRV does not differ between habitually aerobically trained and untrained PMW. However, greater insulin sensitivity was associated with higher cardiac parasympathetic tone in trained PMW only. Exercise training may favorably modulate cardiac autonomic-metabolic interactions in PMW.

History

School

  • Sport, Exercise and Health Sciences

Published in

Menopause

Volume

29

Issue

6

Pages

714 - 722

Publisher

Lippincott, Williams & Wilkins

Version

AM (Accepted Manuscript)

Rights holder

© The North American Menopause Society

Publisher statement

This is a non-final version of an article published in final form in O’Donnell, Emma PhD; Craig, Jennifer PhD Habitual aerobic exercise in healthy postmenopausal women does not augment basal cardiac autonomic activity yet modulates autonomic-metabolic interactions, Menopause: June 2022 - Volume 29 - Issue 6 - p 714-722 doi: 10.1097/GME.0000000000001963.

Acceptance date

23/12/2021

Publication date

2022-06-01

Copyright date

2022

ISSN

1072-3714

eISSN

1530-0374

Language

en

Depositor

Dr Emma O'Donnell. Deposit date: 19 June 2022