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Harnessing applied potential: selective β-hydrocarboxylation of substituted olefins
journal contributionposted on 29.01.2020 by Anas Alkayal, Vlod Tabas, Stephanie Montanaro, Iain Wright, Andrei Malkov, Benjamin Buckley
Any type of content formally published in an academic journal, usually following a peer-review process.
The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.
EPSRC CO2Chem Grand Challenge Network