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Hemodynamic assessment of hollow-fiber membrane oxygenators using computational fluid dynamics in heterogeneous membrane models

journal contribution
posted on 10.03.2021, 09:10 by Daniele Dipresa, Panagiotis Kalozoumis, Michael Pflaum, Ariana Peredo, Bettina Wiegmann, Axel Haverich, Sotiris KorossisSotiris Korossis
Extracorporeal membrane oxygenation (ECMO) has been used clinically for more than 40 years as a bridge to transplantation, with hollow-fiber membrane (HFM) oxygenators gaining in popularity due to their high gas transfer and low flow resistance. In spite of the technological advances in ECMO devices, the inevitable contact of the perfused blood with the polymer hollow-fiber gas-exchange membrane, and the subsequent thrombus formation, limits their clinical usage to only 2-4 weeks. In addition, the inhomogeneous flow in the device can further enhance thrombus formation and limit gas-transport efficiency. Endothelialisation of the blood contacting surfaces of ECMO devices offers a potential solution to their inherent thrombogenicity. However, abnormal shear stresses and inhomogeneous blood flow might affect the function and activation status of the seeded endothelial cells (ECs). In this study, the blood flow through two HFM oxygenators, including the commercially-available iLA® MiniLung Petite Novalung (Xenios AG, Germany) and an experimental one for the rat animal model, was modelled using computational fluid dynamics (CFD), with a view to assessing the magnitude and distribution of the shear stress on the wall of the hollow fibers and flow fields in the oxygenators. This work demonstrated significant inhomogeneity in the flow dynamics of both oxygenators, with regions of high hollow-fiber wall shear stress and regions of stagnant flow, implying both regions of increased flow-induced blood damage and a variable flow-induced stimulation on seeded ECs in a biohybrid setting.

Funding

People Programme (Marie Curie Actions) of the EU 7th Framework Programme FP7/2007–2013/ under the TECAS-ITN (317512)

German Research Foundation through the Cluster of Excellence REBIRTH (EXC 62) and SPP2014 (grant no: 348028075)

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Journal of Biomechanical Engineering

Volume

143

Issue

5

Publisher

ASME

Version

AM (Accepted Manuscript)

Rights holder

© ASME

Publisher statement

This paper was accepted for publication in the journal Journal of Biomechanical Engineering and the definitive published version is available at https://doi.org/10.1115/1.4049808.

Acceptance date

05/01/2021

Publication date

2021-03-08

Copyright date

2021

ISSN

0148-0731

eISSN

1528-8951

Other identifier

Paper No: BIO-20-1042

Language

en

Depositor

Prof Sotiris Korossis. Deposit date: 28 February 2021

Article number

051010