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High-speed laser image analysis of plume angles for pressurised metered dose inhalers: the effect of nozzle geometry

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journal contribution
posted on 06.01.2017, 09:18 by Yang Chen, Paul M. Young, Seamus Murphy, David F. Fletcher, Edward Long, David Lewis, Tanya Church, Daniela Traini
The aim of this study is to investigate aerosol plume geometries of pressurised metered dose inhalers (pMDIs) using a high-speed laser image system with different actuator nozzle materials and designs. Actuators made from aluminium, PET and PTFE were manufactured with four different nozzle designs: cone, flat, curved cone and curved flat. Plume angles and spans generated using the designed actuator nozzles with four solution-based pMDI formulations were imaged using Oxford Lasers EnVision system and analysed using EnVision Patternate software. Reduced plume angles for all actuator materials and nozzle designs were observed with pMDI formulations containing drug with high co-solvent concentration (ethanol) due to the reduced vapour pressure. Significantly higher plume angles were observed with the PTFE flat nozzle across all formulations, which could be a result of the nozzle geometry and material’s hydrophobicity. The plume geometry of pMDI aerosols can be influenced by the vapour pressure of the formulation, nozzle geometries and actuator material physiochemical properties.

Funding

This research was supported by the Australian Research Council Linkage Project funding scheme (project number ARC-LP100200156) and Chiesi Ltd, Chippenham, Wiltshire, UK. Professor Traini is the recipient of an Australian Research Council Future Fellowship (project number FT12010063). Professor Young is the recipient of an Australian Research Council Future Fellowship (project number FT110100996).

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

AAPS PharmSciTech

Volume

18

Pages

782-789

Citation

CHEN, Y. ... et al, 2016. High-speed laser image analysis of plume angles for pressurised metered dose inhalers: the effect of nozzle geometry. AAPS PharmSciTech, 18 (3), pp. 782–789.

Publisher

Springer © American Association of Pharmaceutical Scientists

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

01/06/2016

Publication date

2016-06-17

Notes

The final publication is available at Springer at http://dx.doi.org/10.1208/s12249-016-0564-5

ISSN

1530-9932

eISSN

1530-9932

Language

en

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