File(s) not publicly available
Reason: This item is currently closed access.
Highly enantio- and diastereoselective generation of two quaternary centers in spirocyclopropanation of oxindole derivatives
journal contributionposted on 08.08.2014 by Artur Noole, Natalia S. Sucman, Mikhail A. Kabeshov, Tonis Kanger, Fliur Z. Macaev, Andrei Malkov
Any type of content formally published in an academic journal, usually following a peer-review process.
Spirocyclopropanes: only one out of eight possible stereoisomers was obtained in the asymmetric cascade cyclopropanation of alkylidene oxindoles with ethyl 2-chloroacetoacetate. Improved catalyst design ensured that spirocyclopropyl oxindoles featuring two quaternary centers were synthesized in high yield and high enantio-and diastereoselectivity.
We thank RSC for the International Joint Project grant JP090309 and TUT for travel fellowiship to AN. We acknowledge COST-ORCA action (CM0905) for creating networking and exchange opportunities.