Bishop et al 2009 EIR15.pdf (207.03 kB)
Download fileHuman T lymphocyte migration towards the supernatants of human rhinovirus infected airway epithelial cells: influence of exercise and carbohydrate intake
journal contribution
posted on 2012-10-05, 10:14 authored by Nicolette BishopNicolette Bishop, Gary J. Walker, Michael Gleeson, Fiona A. Wallace, Colin R.A. HewittPhysical stress induces a marked redistribution of T lymphocytes that may be
influenced by carbohydrate (CHO) availability, yet the effect of these on T lymphocyte
migration towards infected tissue is unknown. Therefore, the aim of this
study was to determine the effect of strenuous exercise and CHO ingestion on subsequent
ex vivo lymphocyte migration towards the supernatants of a Human Rhinovirus
(HRV)-infected bronchial epithelial cell line. In a randomised, cross-over,
double-blind design, 7 trained males ran for 2 h at 60% V
.
O2peak on two occasions
with regular ingestion of either a 6.4% w/v glucose and maltodextrin solution
(CHO trial) or placebo solution (PLA trial). Plasma glucose concentration was
higher on CHO than PLA after exercise (P<0.05). Migration of CD4+ and CD8+
cells and their CD45RA+ and CD45RO+ subpopulations towards supernatants
from HRV-infected cells decreased following exercise (main effect for exercise,
P<0.01 for CD4+, CD4+CD45RA+ and CD4+CD45RO+; P<0.05 for CD8+,
CD8+CD45RA+ and CD8+CD45RO+). Migration of CD4+ cells and
CD4+CD45RA+ cells was ~35% and ~30% higher, respectively, on CHO than
PLA at 1 h post-exercise (interaction, P<0.05 for both) and was higher on CHO
than PLA for all other subpopulations (P<0.05, main effect for trial). There was
little effect of exercise or CHO on migration of these cells towards uninfected
(control) cell supernatants or on the proportion of these cells within the peripheral
blood mononuclear cell population. The findings of this study suggest that
physical stress reduces T cell migration towards HRV-infected cell supernatants
and that ingestion of CHO can lessen this effect.
History
School
- Sport, Exercise and Health Sciences
Citation
BISHOP, N. ... et al., 2009. Human T lymphocyte migration towards the supernatants of human rhinovirus infected airway epithelial cells: influence of exercise and carbohydrate intake. Exercise Immunology Review, 15, pp. 127 - 144.Publisher
© Association for the Advancement of Sports MedicineVersion
- VoR (Version of Record)
Publication date
2009Notes
This article was published in the journal, Exercise Immunology Review [© Association for the Advancement of Sports Medicine] and the definitive version is available from PubMed at http://www.ncbi.nlm.nih.gov/pubmed/19957874. The publisher's website is at: http://www.isei.dkISSN
1077-5552Publisher version
Language
- en