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Human, animal and environmental contributors to antibiotic resistance in low resource settings: integrating behavioural, epidemiological and One Health approaches

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journal contribution
posted on 12.04.2018, 10:37 authored by Emily K. Rousham, Leanne Unicomb, Mohammad Aminul Islam
Antibiotic resistance (ABR) is recognised as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals and the environment in low resource settings. This critical review seeks to identify the extent of One Health research on antibiotic resistance in low and middle income countries (LMICs). Existing research has highlighted hotspots for environmental contamination; food-animal production systems that are likely to harbour reservoirs or promote transmission of ABR as well as high and increasing human rates of colonisation with ABR commensal bacteria such as Escherichia coli. However, very few studies have integrated all three components of the One Health spectrum to understand the dynamics of transmission of AMR and the prevalence of community-acquired resistance in humans and animals. Microbiological, epidemiological and social science research is needed at community and population levels across the One Health spectrum in order to fill the large gaps in knowledge of ABR in low resource settings.

Funding

The authors gratefully acknowledge funding support from the UK Antimicrobial Resistance Cross Council Initiative (NERC/BBSRC/MRC) grant no. NE/N019555/1 with additional support from the EPSRC Bridging the Gaps in AMR award EP/M027341/1.

History

School

  • Sport, Exercise and Health Sciences

Published in

Proceedings of the Royal Society B: Biological Sciences

Citation

ROUSHAM, E.K., UNICOMB, L. and ISLAM, M.A., 2018. Human, animal and environmental contributors to antibiotic resistance in low resource settings: integrating behavioural, epidemiological and One Health approaches. Proceedings of the Royal Society B: Biological Sciences, 285: 20180332.

Publisher

© The Authors. Published by The Royal Society.

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

20/03/2018

Publication date

2018

Notes

This paper was accepted for publication in the journal Proceedings of the Royal Society B: Biological Sciences and the definitive published version is available at http://doi.org/10.1098/rspb.2018.0332

ISSN

1471-2954

Language

en