Hydrodynamic stress in orbitally shaken bioreactors.
journal contributionposted on 2015-09-11, 14:28 authored by Stephanie Tissot, Martino Reclari, Samuel Quinodoz, Matthieu Dreyer, Dominique T. Monteil, Lucia Baldi, David Hacker, Mohamed Farhat, Marco DiscacciatiMarco Discacciati, Alfio Quarteroni, Florian M. Wurm
Orbitally shaken bioreactors (OSRs) of nominal volume from 50 mL to 2’000 L have been developed for the cultivation of suspension-adapted mammalian cells. Here we study the hydrodynamics of OSRs for mammalian cells. The results are expected to allow the determination of key parameters for cell cultivation conditions and will facilitate the scale-up of OSRs.
- Mathematical Sciences