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Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems
journal contributionposted on 2016-03-04, 13:59 authored by Alexandra StolzingAlexandra Stolzing, Yahaira Naaldijk, Viktoriya Fedorova, Sebastian Sethe
As the progress of regenerative medicine places ever greater attention on cryopreservation of (stem) cells, tried and tested cryopreservation solutions deserve a second look. This article discusses the use of hydroxyethyl starch (HES) as a cryoprotectant. Charting carefully the recorded uses of HES as a cryoprotectant, in parallel to its further clinical use, indicates that some HES subtypes are a useful supplement to dimethysulfoxide (DMSO) in cryopreservation. However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization. © 2012 Elsevier Ltd.
- Mechanical, Electrical and Manufacturing Engineering
Published inTransfusion and Apheresis Science
Pages137 - 147
CitationSTOLZING, A. ...et al., 2012. Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems. Transfusion and Apheresis Science, 46(2), pp. 137-147.
- VoR (Version of Record)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis paper is in closed access.