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Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems
journal contribution
posted on 2016-03-04, 13:59 authored by Alexandra StolzingAlexandra Stolzing, Yahaira Naaldijk, Viktoriya Fedorova, Sebastian SetheAs the progress of regenerative medicine places ever greater attention on cryopreservation of (stem) cells, tried and tested cryopreservation solutions deserve a second look. This article discusses the use of hydroxyethyl starch (HES) as a cryoprotectant. Charting carefully the recorded uses of HES as a cryoprotectant, in parallel to its further clinical use, indicates that some HES subtypes are a useful supplement to dimethysulfoxide (DMSO) in cryopreservation. However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization. © 2012 Elsevier Ltd.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Transfusion and Apheresis ScienceVolume
46Issue
2Pages
137 - 147Citation
STOLZING, A. ...et al., 2012. Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems. Transfusion and Apheresis Science, 46(2), pp. 137-147.Publisher
© ElsevierVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2012Notes
This paper is in closed access.ISSN
1473-0502eISSN
1878-1683Publisher version
Language
- en
