Hyperbranched polydendrons- a new nanomaterials platform with tuneable permeation (Hatton et al) 2015 Chem Sci.pdf (667.97 kB)
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Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium

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journal contribution
posted on 16.09.2019, 09:35 by Fiona HattonFiona Hatton, Lee M Tatham, Louise R Tidbury, Pierre Chambon, Tao He, Andrew Owen, Steven P Rannard

The development of nanomaterials for advanced therapies requires the formation of versatile platforms that may be tuned to maximize beneficial attributes and minimize unwanted negative behaviour. Additionally, the optimum route of administration is a key consideration of any new treatment and much work has been focused on direct injection into the systemic circulation rather than oral delivery. Here we describe a new approach to polymeric nanoparticle design and present initial results showing the potential for tuneable permeation through a gut epithelium model. Through the use of mixed initiators and branched vinyl polymerization, a series of systematically varying branched polymers have been synthesized and nanoprecipitated. The surprisingly uniform structures have undergone preliminary pharmacological evaluation to establish low cytotoxicity and enhanced permeation through model intestinal epithelial cells. This presents potential opportunities for future developments that may allow oral dosing to result in circulating polymeric nanoparticles; behaviour that may prove clinically desirable to many non-terminal or chronic diseases that utilise nanomedicines but wish to avoid regular or repeated intravenous administration.

Funding

Engineering and Physical Sciences Research Council for a PhD studentship (FL) and grant funding (EP/I038721/1)

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Chemical Science

Volume

6

Issue

1

Pages

326 - 334

Publisher

Royal Society of Chemistry (RSC)

Version

VoR (Version of Record)

Rights holder

© The Royal Society of Chemistry

Acceptance date

03/10/2014

Publication date

2014-10-03

Copyright date

2015

ISSN

2041-6520

eISSN

2041-6539

Language

en

Depositor

Dr Fiona Hatton