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Impaired vascular function in exercising anovulatory premenopausal women is associated with low bone mineral density

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posted on 13.12.2019, 13:50 authored by Emma ODonnellEmma ODonnell, J.L. Scheid, Sarah L. West, Mary Jane De Souza
In estrogen deficient postmenopausal women, osteoporosis share s a common lin k with cardiovascular disease risk, including endothelial dysfunction. The current study sought to examine associations between bone mineral density (BMD) and endothelial function in estrogen deficient premenopausal women with exercise -associated menstrual disturbances. Recreationally trained women (24.3±0.8 years; overall mean±SEM) who were estrogen deficient (amenorrheic or eumenorrheic anovulatory cycles; E2Def; n=13) or estrogen replete (eumenorrheic ovulatory cycles; E2Rep; n=14) were studied . Total body and lumbar BMD (L1 -L4) were determined using dual energy X -ray absorptiometry. Serum markers of oxidative stress (oxidised low -density lipoprotein; OxLDL), energy deficiency (triiodothyronine ) , and bone turnover (osteocalcin, c -telopeptide X, P1NP) were assessed. Estrogen exposure was determined by assessing daily urinary estrone - 3 -glucuronide (E1G) across a monitoring period. Calf blood flow (CBF), an index of endothelial function, was measured using strain -gauge plethysmography. CBF, total body and L1 -L4 BMD, triiodothyronine and E1G were lower (p<0.05), and c -telopeptide crosslinks higher (p<0.05) in E2Def. Osteocalcin and OxLDL did not differ (p>0.05) between groups. L1 -L4 BMD, osteocalcin and E1G were the strongest predictors of CBF ( R 2 =0.615, p<0.001). CBF was the strongest predictor of L1 -L4 BMD ( R 2 =0.478, p<0.001). L1 -L4 (r=0.558, p=0.008) and CBF (r=0.534, p=0.004) were independently correlated with E1G. In young recreationally trained premenopausal women with anovulatory menstrual disturbances, low CBF predicts decreased lumbar BMD, suggesting impaired peripheral endothelial function may predict early unfavorable changes in bone metabolism . This finding may be of relevance in the early detection of cardiovascular and bone health decrements in otherwise healthy estrogen deficient premenopausal women.

Funding

This project was funded in part from by the Arthur Thornton Cardiopulmonary Fund of New Britain General Hospital and the United States Army Medical Research and Material Command Peer Reviewed Medical Research Program (Award Number PR054531).

History

School

  • Sport, Exercise and Health Sciences

Published in

Scandinavian Journal of Medicine & Science in Sports

Volume

29

Issue

4

Pages

544-553

Citation

O'DONNELL, E. ... et al., 2019. Impaired vascular function in exercising anovulatory premenopausal women is associated with low bone mineral density. Scandinavian Journal of Medicine & Science in Sports, 29 (4), pp.544-553.

Publisher

© Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This is the peer reviewed version of the following article: O'DONNELL, E. ... et al., 2019. Impaired vascular function in exercising anovulatory premenopausal women is associated with low bone mineral density. Scandinavian Journal of Medicine & Science in Sports, 29 (4), pp.544-553, which has been published in final form at https://doi.org/10.1111/sms.13354. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Acceptance date

29/11/2018

Publication date

2018-12-12

Copyright date

2019

ISSN

0905-7188

eISSN

1600-0838

Language

en

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Keywords

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