O'Donnell_et_al-2018-Scandinavian_Journal_of_Medicine_&_Science_in_Sports.pdf (773.92 kB)
Download fileImpaired vascular function in exercising anovulatory premenopausal women is associated with low bone mineral density
journal contribution
posted on 2019-12-13, 13:50 authored by Emma ODonnellEmma ODonnell, J.L. Scheid, Sarah L. West, Mary Jane De SouzaIn estrogen deficient postmenopausal women,
osteoporosis share
s a common lin
k with
cardiovascular disease risk, including endothelial dysfunction. The current study sought to examine
associations between bone mineral density (BMD) and endothelial function in estrogen deficient
premenopausal women with exercise
-associated menstrual disturbances. Recreationally trained
women (24.3±0.8 years; overall mean±SEM) who were estrogen deficient
(amenorrheic or
eumenorrheic anovulatory cycles; E2Def; n=13) or estrogen replete (eumenorrheic ovulatory cycles;
E2Rep; n=14) were studied
. Total body and lumbar BMD (L1
-L4) were determined using dual energy
X
-ray absorptiometry. Serum markers of oxidative stress (oxidised low
-density lipoprotein; OxLDL),
energy deficiency
(triiodothyronine
)
, and bone turnover (osteocalcin, c
-telopeptide X, P1NP) were
assessed. Estrogen exposure was determined by assessing
daily urinary estrone
-
3
-glucuronide (E1G)
across a monitoring period. Calf blood flow (CBF), an index of endothelial function, was measured
using strain
-gauge plethysmography. CBF, total body and L1
-L4 BMD, triiodothyronine and E1G were
lower (p<0.05), and c
-telopeptide crosslinks higher (p<0.05) in E2Def. Osteocalcin and OxLDL did not
differ (p>0.05) between groups. L1
-L4 BMD, osteocalcin and E1G were the strongest predictors of
CBF (
R
2
=0.615,
p<0.001). CBF was the strongest predictor of L1
-L4 BMD (
R
2
=0.478,
p<0.001). L1
-L4 (r=0.558, p=0.008) and CBF (r=0.534, p=0.004) were independently correlated with E1G. In young
recreationally trained premenopausal women
with anovulatory menstrual disturbances, low CBF
predicts decreased lumbar BMD, suggesting impaired peripheral endothelial function may predict
early unfavorable changes in bone metabolism
. This finding may be of relevance in the early
detection of cardiovascular and bone health decrements in otherwise healthy estrogen
deficient premenopausal women.
Funding
This project was funded in part from by the Arthur Thornton Cardiopulmonary Fund of New Britain General Hospital and the United States Army Medical Research and Material Command Peer Reviewed Medical Research Program (Award Number PR054531).
History
School
- Sport, Exercise and Health Sciences
Published in
Scandinavian Journal of Medicine & Science in SportsVolume
29Issue
4Pages
544-553Citation
O'DONNELL, E. ... et al., 2019. Impaired vascular function in exercising anovulatory premenopausal women is associated with low bone mineral density. Scandinavian Journal of Medicine & Science in Sports, 29 (4), pp.544-553.Publisher
© WileyVersion
- AM (Accepted Manuscript)
Publisher statement
This is the peer reviewed version of the following article: O'DONNELL, E. ... et al., 2019. Impaired vascular function in exercising anovulatory premenopausal women is associated with low bone mineral density. Scandinavian Journal of Medicine & Science in Sports, 29 (4), pp.544-553, which has been published in final form at https://doi.org/10.1111/sms.13354. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Acceptance date
2018-11-29Publication date
2018-12-12Copyright date
2019ISSN
0905-7188eISSN
1600-0838Publisher version
Language
- en