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Improvements in glycaemic control after acute moderate-intensity continuous or high-intensity interval exercise are greater in South Asians than white Europeans with nondiabetic hyperglycaemia: a randomised crossover study

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posted on 05.10.2020, 13:33 by Jack Sargeant, Charlotte Jelleyman, Nicole Coull, Charlotte Edwardson, Joe Henson, James KingJames King, Kamlesh Khunti, Matthew McCarthy, Alex Rowlands, David StenselDavid Stensel, David Webb, Melanie Davies, Tom Yates
Objective: To examine whether circulating metabolic responses to low-volume high-intensity interval (LV-HIIE) or continuous moderate-intensity aerobic (CME) exercise differ between white Europeans and South Asians with nondiabetic hyperglycaemia (NDH). Research Design and Methods: 13 white Europeans and 10 South Asians (combined median (IQR) age 67 (60–68) years, HbA1c 5.9 (5.8–6.1)% [41.0 (39.9–43.2) mmol·mol-1]) completed three 6-hour conditions (sedentary control [CON], LV-HIIE, CME) in a randomised order. Exercise conditions contained a single bout of LV-HIIE and CME respectively (each ending at 2h), with meals provided at 0 and 3h. Circulating glucose (primary outcome), insulin, insulin resistance index (IRI), triglyceride and non-esterified fatty acids were measured at 0, 0.5, 1, 2, 3, 3.5, 4, 5 and 6h. Data were analysed as post-exercise time-averaged area under the curve (AUC), adjusted for age, sex and pre-exercise AUC. Results: Glucose was similar in each condition and ethnicity, with no condition-by-ethnicity interaction (P≥0.28). However, insulin was lower in LV-HIIE (mean [95% CI]: -44.4 [-23.7, -65.1] mU·L-1) and CME (-33.8 [-13.7, -53.9] mU·L-1) compared to CON. Insulin responses were greater in South Asians (interaction P=0.03) such that values were similar in each ethnicity during exercise conditions, despite being 33% higher in South Asians during CON. IRI followed a similar pattern to insulin. Lipids were unaffected by exercise. Conclusions: Reductions in insulin and insulin resistance after acute LV-HIIE and CME are greater in South Asians than white Europeans with NDH. Further trials are required to examine longer-term impact of LV-HIIE and CME on cardiometabolic health.

Funding

NIHR Leicester Biomedical Research Centre and the NIHR Applied Research Collaboration East Midlands

History

School

  • Sport, Exercise and Health Sciences

Published in

Diabetes Care

Volume

44

Issue

1

Pages

201-209

Publisher

American Diabetes Association

Version

AM (Accepted Manuscript)

Rights holder

© American Diabetes Association

Publisher statement

This paper was accepted for publication in the journal Diabetes Care and the definitive published version is available at https://doi.org/10.2337/dc20-1393

Acceptance date

04/10/2020

Publication date

2020-11-06

Copyright date

2021

ISSN

0149-5992

eISSN

1935-5548

Language

en

Depositor

Dr James King Deposit date: 4 October 2020