O-Donnell_et_al-2020-Scandinavian_Journal_of_Medicine_&_Science_in_Sports.pdf (1.57 MB)
Indexes of aortic wave reflection are not augmented in estrogen-deficient physically active premenopausal women
journal contribution
posted on 2020-03-04, 15:15 authored by Emma ODonnellEmma ODonnell, Jack M Goodman, John S Floras, Paula J HarveyBackground
Hypoestrogenemia due to menopause is associated with increased cardiovascular disease risk, in part due to elevated indexes of aortic wave reflection (AWRI) and central (aortic) blood pressure. We sought to investigate whether AWRI and central blood pressure are also augmented in hypoestrogenic exercise‐trained premenopausal women with functional hypothalamic amenorrhea (ExFHA).
Methods
In age‐ (pooled mean±SEM, 24±1 years), BMI‐ (21±1 kg/m2), and cardiorespiratory fitness‐matched (45±2 ml/kg/min) eumenorrheic ovulatory (ExOv; n=11) and ExFHA women (n=10), we assessed aortic blood pressure and wave form characteristics (augmentation index and wave reflection amplitude) obtained from radial pressure waves (applanation tonometry). Doppler ultrasound determined cardiac output (CO) and total peripheral resistance (TPR). Measures were recorded before and one‐hour after 45 minutes of moderate intensity exercise to determine the influence of exercise‐induced increases in nitric oxide.
Results
Pre‐exercise, AIx75, central systolic BP (SBPc), and CO were lower (p<0.05) and TPR higher (p<0.05) in ExFHA. Post‐exercise, AIx75 was unchanged (p>0.05) in ExFHA but was lowered (p<0.05) in ExOv. Both groups demonstrated increased CO, and lowered SBPc and TPR, yet TPR remained higher (p<0.05), and CO and SBPc lower (p<0.05) in ExFHA.
Conclusions
Despite hypoestrogenemia, functional compliance of the central arteries and central BP are not augmented, yet TPR is higher, in ExFHA versus ExOv. An acute bout of dynamic exercise did not alter AIx75 in ExFHA, suggesting blunted vascular responsiveness to exercise‐induced increases in nitric oxide, possibly due to augmented vascular tone. These findings have relevance in understanding the vascular consequences of hypoestrogenemia during the premenopausal years.
Funding
Pfizer Cardiovascular Independent Research Award (NRA 3840028)
History
School
- Sport, Exercise and Health Sciences
Published in
Scandinavian Journal of Medicine & Science in SportsVolume
30Issue
6Pages
1054 - 1063Publisher
John Wiley & Sons LtdVersion
- AM (Accepted Manuscript)
Rights holder
© John Wiley & Sons A/SPublisher statement
This is the peer reviewed version of the following article: O'DONNELL, E. ... et al, 2020. Indexes of aortic wave reflection are not augmented in estrogen-deficient physically active premenopausal women. Scandinavian Journal of Medicine & Science in Sports, 30 (6), pp.1054-1063, which has been published in final form at https://doi.org/10.1111/sms.13647. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Acceptance date
2020-02-17Publication date
2020-03-02Copyright date
2020ISSN
0905-7188eISSN
1600-0838Publisher version
Language
- en
Depositor
Dr Emma O'Donnell. Deposit date: 4 March 2020Usage metrics
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