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Influence of short-term hyperenergetic, high-fat feeding on appetite, appetite-related hormones, and food reward in healthy men

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posted on 28.08.2020, 08:14 authored by Alice ThackrayAlice Thackray, Scott WillisScott Willis, David Clayton, David Broom, Graham Finlayson, Fernanda Goltz, Jack Sargeant, Rachel Woods, David StenselDavid Stensel, James KingJames King
Short-term overfeeding may provoke compensatory appetite responses to correct the energy surplus. However, the initial time-course of appetite, appetite-related hormone, and reward-related responses to hyperenergetic, high-fat diets (HE-HFD) are poorly characterised. Twelve young healthy men consumed a HE-HFD (+50% energy, 65% fat) or control diet (36% fat) for seven days in a randomised crossover design. Mean appetite perceptions were determined during an oral glucose tolerance test (OGTT) before and after each diet. Fasted appetite perceptions, appetite-related hormones, and reward parameters were measured pre-diet and after 1-, 3- and 7-d of each diet. The HE-HFD induced a pre-to-post diet suppression in mean appetite during the OGTT (all ratings P ≤ 0.058, effect size (d) ≥ 0.31), and reduced the preference for high-fat vs. low-fat foods (main effect diet P = 0.036, d = 0.32). Fasted leptin was higher in the HE-HFD than control diet (main effect diet P < 0.001, d = 0.30), whilst a diet-by-time interaction (P = 0.036) revealed fasted acylated ghrelin was reduced after 1-, 3- and 7-d of the HE-HFD (all P ≤ 0.040, d ≥ 0.50 vs. pre-diet). Appetite perceptions and total peptide YY in the fasted state exhibited similar temporal patterns between the diets (diet-by-time interaction P ≥ 0.077). Seven days of high-fat overfeeding provokes modest compensatory changes in subjective, hormonal, and reward-related appetite parameters.

Funding

National Institute for Health Research (NIHR) Leicester Biomedical Research Centre.

History

School

  • Sport, Exercise and Health Sciences

Published in

Nutrients

Volume

12

Issue

9

Publisher

MDPI AG

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

28/08/2020

Publication date

2020-08-29

Copyright date

2020

eISSN

2072-6643

Language

en

Depositor

Dr James King. Deposit date: 28 August 2020

Article number

2635