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Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review

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journal contribution
posted on 04.03.2019, 11:26 authored by Carolina Cabral‐Santos, Edson Alves de Lima Junior, Isabela Maia da Cruz Fernandes, Rafael Zambelli Pinto, Jose Cesar Rosa‐Neto, Nicolette BishopNicolette Bishop, Fabio S. Lira
Purpose: Interleukin 10 (IL‐10) is a cytokine that plays a critical role with potent anti‐ inflammatory properties when produced during exercise, limiting host immune response to pathogens and preventing tissue damage. The purpose of this systematic review was to assess the response of IL‐10 after acute exercise session in healthy adults. Methods: Databases of Ovid Medline (1978–2016), CINAHL (1998–2016), EMBASE (2003–2016), SportDiscus (1990–2016), and Web of Science library (1990–2016) were carefully screened. Clinical trials comparing exercise types in healthy individuals were included for pooled analysis. The trials of exercise were methodologically appraised by PEDro Scale. Results: Twelve randomized controlled and crossover trials containing 176 individuals were identified for inclusion. The Kruskal‐Wallis test showed no significant differences between type of exercise and the corresponding values in IL‐ 10 [X2(4) = 2.878; p = 0.449]. The duration of exercise was significantly correlated with increase in IL‐10 changes (Pearson’s r = 1.00, 95%CI: 0.015–0.042, p < 0.0001) indicating that 48% of the variation in IL‐10 levels can be explained by the duration of the exercise performed. In addition, despite a linear increase, we did not find a significant correlation with the intensity of exercise and IL‐10 changes (Pearson’s r = 0.218, 95%CI: −0.554–0.042, p < 0.035). Conclusion: Overall, the duration of the exercise is the single most important factor determining the magnitude of the exercise‐induced increase of plasma IL‐10.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo, Grant/Award Numbers: 2015/ 17068‐2, 2016/1409‐8, 2016/16712‐8, 2015/ 26148‐0

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Cellular Physiology

Volume

234

Issue

7

Pages

9956-9965

Citation

CABRAL-SANTOS, C. ... et al., 2018. Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review. Journal of Cellular Physiology, 234 (7), pp.9956-9965.

Publisher

© Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This is the peer reviewed version of the following article: CABRAL-SANTOS, C. ... et al., 2018. Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review. Journal of Cellular Physiology, 234 (7), pp.9956-9965, which has been published in final form at https://doi.org/10.1002/jcp.27920. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Acceptance date

25/10/2018

Publication date

2018-12-07

Copyright date

2019

ISSN

0021-9541

eISSN

1097-4652

Language

en