Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients
journal contributionposted on 03.12.2021, 09:05 by Patrick Highton, Daniel March, Darren Churchward, Charlotte Grantham, Hannah Young, Matthew Graham-Brown, Seila Estruel, Naomi Martin, Nigel Brunskill, Alice Smith, James Burton, Nicolette BishopNicolette Bishop
Patients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact of regular, moderate-intensity IDC on circulating MPs and inflammatory markers in unit-based HD patients.
Patients were cluster-randomised to intervention (n = 20, age: 51.4 ± 18.1 years, body mass: 77.6 ± 18.3 kg, mean ± SD) or no-exercise control (n = 20, 56.8 ± 14.0 years, 80.5 ± 26.5 kg). Intervention participants completed 30 min of moderate intensity (rating of perceived exertion [RPE] of 12–14) IDC, thrice weekly for 6 months. Pre-dialysis venous blood samples were obtained at 0, 3 and 6 months. Circulating MP phenotypes, cytokines, chemokine and MP TF expression were quantified using flow cytometry and cytometric bead array assays.
Despite high exercise compliance (82%), no IDC-dependent effects were observed for any MP, cytokine or chemokine measure (p ≥ 0.051, ηρ2 ≤ 0.399) other than TNF-α (p = 0.001, ηρ2 = 0.186), though no significance was revealed upon post hoc analysis.
Six months of regular, moderate-intensity IDC had no effect on MPs, cytokines or chemokines. This suggests that the exercise did not exacerbate thrombotic or inflammatory status, though further functional assays are required to confirm this.
ISRCTN1129707, prospectively registered on 05/03/2015.
The CYCLE-HD study was funded by a grant from the National Institute of Health Research (CS-2013-13-014) and supported by the Stoneygate Trust. This research was also supported by the NIHR Leicester Biomedical Research Centre. Hannah Young is supported by a grant from the NIHR (DRF-2016-09-015).
- Sport, Exercise and Health Sciences