Final manuscript-ie-2021-00491w.pdf (2.36 MB)
Download fileInvestigation of agglomeration in the presence of oiling out in the antisolvent crystallization process
journal contribution
posted on 2021-04-15, 13:51 authored by Liping Wang, Ying Bao, Zhuang Sun, Valerie PinfieldValerie Pinfield, Qiuxiang Yin, Huaiyu YangHuaiyu YangOiling out during the crystallization process often generates agglomeration. This research is focused on the control of agglomeration in the antisolvent crystallization of the propylparaben-ethanol-water system in the presence of oiling out, that is, the liquid-liquid phase separation phenomenon. Crystallization trajectories were designed to start from a homogeneous solution with different initial concentrations of propylparaben in ethanol, crossing the liquid-liquid phase separation region in the ternary phase diagram by adding the antisolvent of water. A combination of process analytical technology tools, such as focused beam reflectance measurement, particle visual monitoring, and attenuated total reflectance ultraviolet/visible, enabled the detection of the different stages of the oiling out crystallization process, including the droplet formation of the dispersed phase, prenucleation, nucleation, and crystal growth both in the liquid-liquid phase-separated system and in the homogeneous solution. The crystals tended to form normally at higher initial concentrations of propylparaben while tending to agglomerate at a lower initial concentration. Crystallization experiments were also performed with the addition of sonication, with variation in sonication start time, duration, and power. The results showed that ultrasound could reduce the agglomeration dependent on the initial application time. The mechanism of crystallization and agglomeration in oiling out was discussed.
Funding
China Scholarship Council, National Natural Foundation of China (No. 21576187 and No. 21776203)
Tianjin Municipal Natural Science Foundation (No. 18JCYBJC21100)
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Industrial & Engineering Chemistry ResearchVolume
60Issue
10Pages
4110 - 4119Publisher
American Chemical Society (ACS)Version
- AM (Accepted Manuscript)
Rights holder
© American Chemical SocietyPublisher statement
“This document is the Accepted Manuscript version of a Published Work that appeared in final form in Industrial & Engineering Chemistry Research, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.iecr.1c00491Acceptance date
2021-02-18Publication date
2021-03-03Copyright date
2021ISSN
0888-5885eISSN
1520-5045Publisher version
Language
- en