acs.cgd.6b01683.pdf (2.98 MB)
Investigation of the evolution of crystal size and shape during temperature cycling and in the presence of a polymeric additive using combined process analytical technologies
journal contribution
posted on 2017-08-11, 13:21 authored by Elena Simone, Anneke R. Klapwijk, Chick C. Wilson, Zoltan NagyZoltan NagyCrystal size and shape can be manipulated to enhance the qualities of the final product. In this work the steady-state shape and size of succinic acid crystals, with and without a polymeric additive (Pluronic P123) at 350 mL, scale is reported. The effect of the amplitude of cycles as well as the heating/cooling rates is described, and convergent cycling (direct nucleation control) is compared to static cycling. The results show that the shape of succinic acid crystals changes from plate- to diamond-like after multiple cycling steps, and that the time required for this morphology change to occur is strongly related to the type of cycling. Addition of the polymer is shown to affect both the final shape of the crystals and the time needed to reach size and shape steady-state conditions. It is shown how this phenomenon can be used to improve the design of the crystallization step in order to achieve more efficient downstream operations and, in general, to help optimize the whole manufacturing process.
Funding
This work is funded through the European Research Council grant no. [280106-CrySys], EPSRC grants EP/I033459/1 (CMAC Centre) and EP/K503289/1 (Doctoral Training Centre in Continuous Manufacturing and Crystallisation).
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Crystal Growth and DesignVolume
17Issue
4Pages
1695 - 1706Citation
SIMONE, E. ...et al., 2017. Investigation of the evolution of crystal size and shape during temperature cycling and in the presence of a polymeric additive using combined process analytical technologies. Crystal Growth and Design, 17(4), pp. 1695-1706.Publisher
American Chemical Society (ACS)Version
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2017-03-01Publication date
2017-03-09Copyright date
2017Notes
This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. Special Issue published as part of a Crystal Growth and Design virtual special issue of selected papers presented at the 12th International Workshop on the Crystal Growth of Organic Materials (CGOM12 Leeds, UK).ISSN
1528-7483eISSN
1528-7505Publisher version
Language
- en