Varela-Mato_s12966-019-0892-4.pdf (495.82 kB)
Download file

Isotemporal substitution of inactive time with physical activity and time in bed: Cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

Download (495.82 kB)
journal contribution
posted on 22.01.2020, 14:32 authored by AM Galmes-Panades, Veronica Varela-MatoVeronica Varela-Mato, J Konieczna, J Wärnberg, MÁ Martínez-González, J Salas-Salvadó, D Corella, H Schröder, J Vioque, ÁM Alonso-Gómez, JA Martínez, L Serra-Majem, R Estruch, FJ Tinahones, J Lapetra, X Pintó, JA Tur, A Garcia-Rios, B Riquelme-Gallego, JJ Gaforio, P Matía-Martín, L Daimiel, RM Micó Pérez, J Vidal, C Vázquez, E Ros, A Garcia-Arellano, A Díaz-López, EM Asensio, O Castañer, F Fiol, LA Mira-Castejón, A Moreno Rodríguez, JC Benavente-Marín, I Abete, L Tomaino, R Casas, FJ Barón López, JC Fernández-García, JM Santos-Lozano, A Galera, CM Mascaró, C Razquin, C Papandreou, O Portoles, KA Pérez-Vega, M Fiol, L Compañ-Gabucio, J Vaquero-Luna, M Ruiz-Canela, N Becerra-Tomás, M Fitó, D Romaguera
© 2019 The Author(s). Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-To-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results: Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions: Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. Trial registration: The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

Funding

European Research Council grant (Advanced Research Grant 2013–2019; 340918)

Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018)

The PROMETEO/2017/017 grant from the Generalitat Valenciana;

History

School

  • Sport, Exercise and Health Sciences

Published in

International Journal of Behavioral Nutrition and Physical Activity

Volume

16

Issue

1

Publisher

BMC

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by BMC under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

27/11/2019

Publication date

2019-12-23

Copyright date

2019

eISSN

1479-5868

Language

en

Location

England

Depositor

Dr Veronica Varela-Mato . Deposit date: 20 January 2020

Article number

137