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Isoxazole to oxazole: a mild and unexpected transformation
journal contributionposted on 2015-02-27, 11:02 authored by Ray Jones, Alexander Chatterley, Romain Marty, W. Martin Owton, Mark ElsegoodMark Elsegood
3-Aryltetrahydrobenzisoxazoles prepared en route to the coleophomone natural products and analogues, were found to undergo a remarkable base-mediated rearrangement to 2-aryltetrahydrobenzoxazoles. The scope of this unprecedented, facile transformation was probed: a range of analogues was produced, a mechanism proposed, and an application demonstrated by synthesis of a known herbicidal compound.
Published inCHEMICAL COMMUNICATIONS
Pages1112 - 1115 (4)
CitationJONES, R.C.F. ... et al., 2015. Isoxazole to oxazole: a mild and unexpected transformation. Chemical Communications, 51 (6), pp. 1112 - 1115.
PublisherRoyal Society of Chemistry
- VoR (Version of Record)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/
NotesThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.