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Job strain and the risk of stroke: an individual-participant data meta-analysis

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journal contribution
posted on 29.10.2015, 13:58 by Eleonor I. Fransson, Solja T. Nyberg, Katriina Heikkila, Mark Hamer
Background and Purpose—Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. Methods—We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke. Results—In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status. Conclusion—Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.


Funding for the IPD-Work Consortium



  • Sport, Exercise and Health Sciences

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FRANSSON, E.I. ... et al., 2015. Job strain and the risk of stroke: an individual-participant data meta-analysis. Stroke, 46 (2), pp. 557-559.


© American Heart Association, Inc.


AM (Accepted Manuscript)

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This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at:

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The authors are: Eleonor I. Fransson, PhD; Solja T. Nyberg, MSc; Katriina Heikkilä, PhD; Lars Alfredsson, PhD; Jakob B. Bjorner, MD, PhD; Marianne Borritz, MD, PhD; Hermann Burr, PhD; Nico Dragano, PhD; Goedele A. Geuskens, PhD; Marcel Goldberg, MD, PhD; Mark Hamer, PhD; Wendela E. Hooftman, PhD; Irene L. Houtman, PhD; Matti Joensuu, MSc; Markus Jokela, PhD; Anders Knutsson, PhD; Markku Koskenvuo, MD, PhD; Aki Koskinen, MSc; Meena Kumari, PhD; Constanze Leineweber, PhD; Thorsten Lunau, MSc; Ida E.H. Madsen, PhD; Linda L. Magnusson Hanson, PhD; Martin L. Nielsen, MD, PhD; Maria Nordin, PhD; Tuula Oksanen, MD, PhD; Jaana Pentti, BSc; Jan H. Pejtersen, PhD; Reiner Rugulies, PhD; Paula Salo, PhD; Martin J. Shipley, MSc; Andrew Steptoe, DPh; Sakari B. Suominen, MD, PhD; Töres Theorell, MD, PhD; Salla Toppinen-Tanner, PhD; Jussi Vahtera, MD, PhD; Marianna Virtanen, PhD; Ari Väänänen, PhD; Peter J.M. Westerholm, MD, PhD; Hugo Westerlund, PhD; Marie Zins, MD, PhD; Annie Britton, PhD; Eric J. Brunner, PhD; Archana Singh-Manoux, PhD; G. David Batty, PhD; Mika Kivimäki, PhD. This article was published in the journal, Stroke [© American Heart Association, Inc.] and the definitive version is available at:





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